Wilkinson I D, Paley M N, Hall-Craggs M A, Chinn R J, Chong W K, Sweeney B J, Kendall B E, Miller R F, Newman S P, Harrison M J
Department of Medical Physics and Bioengineering, Middlesex Hospital, University College London Hospitals Trust, UK.
Magn Reson Imaging. 1996;14(4):365-72. doi: 10.1016/0730-725x(95)02109-7.
A prospective, cross-sectional study was designed to determine the magnetic resonance relaxation times of cerebral white matter in human immunodeficiency virus (HIV) infected individuals. T1 and T2 were estimated at 1.5 T using four-point methods. Seventy-five HIV-1 seropositive subjects, 48 seronegative blood donors, and 17 seronegative homosexual men were studied. Associations between relaxometry and clinical classification, neurological status, immunological status, and qualitative MRI were investigated. Statistically significant differences in white matter T1 relaxation time were found comparing low-risk control and AIDS groups (p < .005), seropositive subjects with neurological signs and those without (p < .005), and subjects with low (CD4 < or = 200 x 10(6)/l) and high (CD4 > 200 x 10(6)/1) CD4 cell counts (p < .05). These findings add to the body of information that reveals no HIV-related change in the brain before the onset of symptomatic immunosuppression and go someway to validating the previous visually rated, qualitative findings. Statistically significant difference in white matter T2 relaxation time were also found comparing the two control groups (p < .005) highlighting the need for appropriate controls.
一项前瞻性横断面研究旨在确定人类免疫缺陷病毒（HIV）感染者脑白质的磁共振弛豫时间。使用四点法在1.5T下估计T1和T2。研究了75名HIV-1血清阳性受试者、48名血清阴性献血者和17名血清阴性同性恋男性。研究了弛豫测量与临床分类、神经状态、免疫状态和定性MRI之间的关联。比较低风险对照组和艾滋病组（p <.005）、有神经体征和无神经体征的血清阳性受试者（p <.005）以及CD4细胞计数低（CD4≤200×10⁶/l）和高（CD4>200×10⁶/l）的受试者时，发现脑白质T1弛豫时间存在统计学显著差异（p <.05）。这些发现增加了在有症状的免疫抑制发作之前大脑中未发现与HIV相关变化的信息，并在一定程度上验证了先前视觉评分的定性发现。比较两个对照组时，脑白质T2弛豫时间也存在统计学显著差异（p <.005），突出了使用适当对照组的必要性。
