Akerman M, Willén H, Carlén B, Mandahl N, Mertens F
Departments of Clinical Pathology & Cytology, University Hospital, Lund, Sweden.
Cytopathology. 1996 Jun;7(3):187-200. doi: 10.1046/j.1365-2303.1996.38782397.x.
A retrospective study of 25 FNAs (11 aspirates from primary tumours and 14 from recurrencies and metastases) from 15 synovial sarcomas was performed. The cytological findings were correlated with the histopathology and the value of immunohistochemical and electron microscopic examination as well as DNA-ploidy and cytogenetic analysis for diagnosis were assessed. A reproducible cellular pattern with a reliable diagnosis of spindle cell sarcoma was possible provided that the aspirates were cell rich. However, a true biphasic pattern indicative of synovial sarcoma was only seen in one of the 25 specimens. Electron microscopic examination of the aspirates was a valuable adjunctive diagnostic method, whereas immunocytochemistry and DNA-ploidy analysis were not. Immunohistochemical, electron microscopic and cytogenetic analysis were all valuable ancillary methods when performed on surgical specimens. Malignant haemangiopericytoma and fibrosarcoma were the most important differential diagnoses in the FNA specimens.
对15例滑膜肉瘤的25次细针穿刺抽吸活检（FNA）（11例来自原发性肿瘤，14例来自复发病灶和转移灶）进行了回顾性研究。将细胞学检查结果与组织病理学进行关联，并评估免疫组织化学、电子显微镜检查以及DNA倍体和细胞遗传学分析在诊断中的价值。如果穿刺抽吸物富含细胞，则有可能获得可重复的细胞模式并做出可靠的梭形细胞肉瘤诊断。然而，在25个标本中只有1个观察到了提示滑膜肉瘤的真正双相模式。对穿刺抽吸物进行电子显微镜检查是一种有价值的辅助诊断方法，而免疫细胞化学和DNA倍体分析则不然。对手术标本进行免疫组织化学、电子显微镜和细胞遗传学分析均为有价值的辅助方法。恶性血管外皮细胞瘤和纤维肉瘤是FNA标本中最重要的鉴别诊断。
