Nève J
Université Libre de Bruxelles, Institut de Pharmacie, Belgium.
J Cardiovasc Risk. 1996 Feb;3(1):42-7.
Selenium is a powerful antioxidant regulating the activity of the glutathione peroxidase enzymes, which catalyse the detoxification of hydrogen peroxide and organic hydroperoxides. Selenium deficiency has been implicated in the aetiopathogeny of Keshan disease, an endemic cardiomyopathy observed in China, and in other cases of congestive cardiomyopathy in subjects on artificial nutrition. However, the evidence from case-control and prospective studies for an association between low selenium status and cardiovascular diseases remains controversial. Mechanisms whereby selenium protects against such diseases include increased resistance of low-density lipoproteins against oxidative modification, modulation of prostaglandin synthesis and platelet aggregation, and protection against toxic heavy metals. The therapeutic benefit of selenium administration in the prevention and treatment of cardiovascular diseases still remains insufficiently documented.
硒是一种强大的抗氧化剂，可调节谷胱甘肽过氧化物酶的活性，这些酶催化过氧化氢和有机氢过氧化物的解毒过程。在中国观察到的一种地方性心肌病——克山病的病因发病机制中以及在接受人工营养的受试者的其他充血性心肌病病例中，均涉及硒缺乏。然而，病例对照研究和前瞻性研究关于低硒状态与心血管疾病之间关联的证据仍存在争议。硒预防此类疾病的机制包括增强低密度脂蛋白对氧化修饰的抵抗力、调节前列腺素合成和血小板聚集以及抵御有毒重金属。补充硒在预防和治疗心血管疾病方面的治疗益处仍缺乏充分的文献记载。
