Orallo F
Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, La Corunai, Spain.
Pharmacol Ther. 1996;69(3):153-71. doi: 10.1016/0163-7258(95)02042-x.
Ca2+ plays an important role in the contraction of skeletal, cardiac, and smooth muscle, as well as in a number of important processes, such as secretion and neuronal activity. In this review, I focus on the various mechanisms by which cytosolic Ca2+ concentration is regulated in vascular smooth muscle, in the resting state and during activation. Particular attention is paid to the calcium pumps of the plasmalemma and the sarcoplasmic reticulum, to the inositol 1,4,5-trisphosphate- and ryanodine-sensitive calcium channels of the sarcoplasmic reticulum, and to voltage-dependent and voltage-independent calcium channels of the plasmalemma.
钙离子（Ca2+）在骨骼肌、心肌和平滑肌的收缩过程中，以及在一些重要生理过程（如分泌和神经元活动）中发挥着重要作用。在这篇综述中，我将重点关注在静息状态和激活过程中，血管平滑肌细胞质中钙离子浓度的各种调节机制。特别关注质膜和肌浆网的钙泵、肌浆网中对肌醇1,4,5-三磷酸和兰尼碱敏感的钙通道，以及质膜上的电压依赖性和电压非依赖性钙通道。
