Blomquist M, Karlsson M, Karlsson M
Radiation Physics Department, Umeå University, Sweden.
Radiother Oncol. 1996 Jun;39(3):271-86. doi: 10.1016/0167-8140(96)01742-2.
The calculation of an electron dose distribution in a patient is a difficult problem because of the presence of tissue and surface inhomogeneities. Verification of the dose planning system is therefore essential. In this investigation, a novel method is used to evaluate a commercially available system (Helax-TMS), at electron energies between 10 and 50 MeV, both for a conventional treatment unit and an MLC-collimated scanned beam unit with a helium-filled treatment head. First, the experiments were designed to verify the local beam database and some fundamental characteristics of the electron beam calculations. Secondly, a number of generalised situations that would be encountered in the clinical treatment planning were evaluated oblique incidence, field shaping with multi-leaf collimator, bolus edges, and air cavities. Dose distributions in two generalised anatomical phantoms simulating a neck and a nose were also analysed. The results have, when so possible, been presented as the dose ratio within the 'flattened area' for dose profiles and down to the 'treatment depth' (80% dose level) for depth doses. In the penumbra region and in the dose fall-off region, the comparison has been represented by the distance deviation between calculated and measured dose profiles or depth doses. A new tool, 'volume integration', was used to evaluate the deviations from a more clinical point of view. Most results were within +/- 2% in dose for volumes larger than a sphere with a diameter of 15 mm, or +/- 2 mm in position. Dose deviations were generally found for oblique incidences and below heterogeneities such as small air cavities and bolus edges in limited volumes.
由于存在组织和表面不均匀性,计算患者体内的电子剂量分布是一个难题。因此,剂量规划系统的验证至关重要。在本研究中,采用了一种新方法来评估一种商用系统(Helax-TMS),该系统适用于能量在10至50 MeV之间的电子,用于传统治疗单元以及配备充氦治疗头的MLC准直扫描束单元。首先,设计实验以验证局部束流数据库和电子束计算的一些基本特性。其次,评估了临床治疗计划中可能遇到的一些一般情况——斜入射、多叶准直器的射野成形、加填充物边缘和空气腔。还分析了模拟颈部和鼻子的两个一般解剖模型中的剂量分布。只要有可能,结果就以剂量剖面“平坦区域”内的剂量比以及深度剂量至“治疗深度”(80%剂量水平)的形式呈现。在半值层区域和剂量下降区域,比较以计算剂量剖面与测量剂量剖面或深度剂量之间的距离偏差表示。使用一种新工具“体积积分”从更临床的角度评估偏差。对于直径大于15 mm的球体体积,大多数结果在剂量上的偏差在±2%以内,或在位置上的偏差在±2 mm以内。对于斜入射以及有限体积内的小空气腔和加填充物边缘等不均匀性下方,通常会发现剂量偏差。