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Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.

作者信息

Cobb M H, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M

机构信息

The University of Texas Southwestern Medical Center, Department of Pharmacology, Dallas 75235, USA.

出版信息

Adv Pharmacol. 1996;36:49-65. doi: 10.1016/s1054-3589(08)60576-1.

DOI:10.1016/s1054-3589(08)60576-1
PMID:8783554
Abstract
摘要

相似文献

1
Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.
Adv Pharmacol. 1996;36:49-65. doi: 10.1016/s1054-3589(08)60576-1.
2
Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.ERK1激活位点突变体的表征及其对MEK1和MEK2识别的影响。
J Biol Chem. 1996 Feb 23;271(8):4230-5. doi: 10.1074/jbc.271.8.4230.
3
Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex.通过T细胞受体复合物连接刺激的人T细胞中,与年龄相关的丝裂原活化蛋白激酶p44mapk/ERK1和p42mapk/ERK2激活的减少。
Cell Immunol. 1996 Mar 15;168(2):201-10. doi: 10.1006/cimm.1996.0067.
4
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.由MEK和MKK亚型定义的独立人类丝裂原活化蛋白激酶信号转导途径。
Science. 1995 Feb 3;267(5198):682-5. doi: 10.1126/science.7839144.
5
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.丝裂原活化蛋白激酶ERK2的一种组成型活性核形式足以促进神经突生长和细胞转化。
Curr Biol. 1998 Oct 22;8(21):1141-50. doi: 10.1016/s0960-9822(07)00485-x.
6
Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.人类丝裂原活化蛋白激酶激酶激酶介导应激诱导的丝裂原活化蛋白激酶级联反应激活。
Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):599-609. doi: 10.1042/bj3360599.
7
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.丝裂原活化蛋白激酶激酶1(MEKK1)使丝裂原活化蛋白激酶激酶1(MEK1)和丝裂原活化蛋白激酶激酶2(MEK2)磷酸化,但不会导致丝裂原活化蛋白激酶(MAPK)的激活。
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6808-12. doi: 10.1073/pnas.92.15.6808.
8
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.丝裂原活化蛋白激酶激活丝氨酸/苏氨酸激酶Mnk1和Mnk2。
EMBO J. 1997 Apr 15;16(8):1909-20. doi: 10.1093/emboj/16.8.1909.
9
Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases.丝裂原活化蛋白激酶/细胞外信号调节激酶(MAP/ERK)对丝裂原活化蛋白激酶(MAP激酶)的磷酸化涉及丝裂原活化蛋白激酶的多个区域。
J Biol Chem. 1999 Jun 11;274(24):16988-94. doi: 10.1074/jbc.274.24.16988.
10
The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells.细胞外信号调节蛋白激酶(Erks)是JB6细胞中紫外线诱导的AP-1激活所必需的。
Oncogene. 1999 May 6;18(18):2828-35. doi: 10.1038/sj.onc.1202639.

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Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer.用毛细管等电聚焦免疫分析技术研究非小细胞肺癌中动态癌蛋白磷酸化和针对治疗的药物反应。
Mol Cancer Ther. 2013 Nov;12(11):2601-13. doi: 10.1158/1535-7163.MCT-13-0074. Epub 2013 Aug 26.
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Different protein kinase C isoforms determine growth factor specificity in neuronal cells.不同的蛋白激酶C亚型决定神经元细胞中的生长因子特异性。
Mol Cell Biol. 2000 Aug;20(15):5392-403. doi: 10.1128/MCB.20.15.5392-5403.2000.
3
Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells.
蛋白激酶Cδ介导神经元细胞中丝裂原活化蛋白激酶的神经源性激活而非有丝分裂原激活。
Mol Cell Biol. 1999 Jun;19(6):4209-18. doi: 10.1128/MCB.19.6.4209.
4
Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.细胞外信号调节激酶7(ERK7),一种新型的ERK,其C末端结构域可调节其活性、细胞定位和细胞生长。
Mol Cell Biol. 1999 Feb;19(2):1301-12. doi: 10.1128/MCB.19.2.1301.