Rajeshwari K, Jaggi N, Aggarwal V, Kalra K K, Mittal S K, Baveja U
Department of Pediatrics, Maulana Azad Medical College, New Delhi.
Trop Gastroenterol. 1996 Apr-Jun;17(2):70-6.
Giardia has been frequently implicated as a causative agent for acute as well as chronic diarrheal diseases in children. The present study was aimed at exploring the determinants of manifestations of Giardiasis in childhood, in relation to various host and parasite related factors. A total of 200 children with acute (100), chronic (50) or without (50) diarrhea in last 15 days were recruited for the study and evaluated with regards to nutritional status, serum immunoglobulins, secretory IgA levels, presence of Giardia in stool/duodenal aspirate/duodenal biopsy specimen and for associated infections. Lysates from acute giardiasis cases were further studied for zymodeme (banding) pattern. After correlation of all investigations, humoral immune defect in the host was found to be the major determinant of whether the Giardial infestation would be symptomatic or not, while associated bacterial infections and zymodeme patterns were not found to be important in determining the pathogenicity or presentation of giardiasis.
贾第虫常被认为是儿童急慢性腹泻疾病的病原体。本研究旨在探讨儿童贾第虫病临床表现的决定因素，及其与各种宿主和寄生虫相关因素的关系。本研究共招募了200名儿童，其中100名患有急性腹泻，50名患有慢性腹泻，50名在过去15天内未出现腹泻，对他们的营养状况、血清免疫球蛋白、分泌型IgA水平、粪便/十二指肠抽吸物/十二指肠活检标本中贾第虫的存在情况以及相关感染进行了评估。对急性贾第虫病病例的裂解物进一步研究其酶谱（条带）模式。在对所有调查结果进行相关性分析后，发现宿主的体液免疫缺陷是贾第虫感染是否出现症状的主要决定因素，而相关细菌感染和酶谱模式在确定贾第虫病的致病性或表现方面并不重要。
