Judd R, Deckelbaum R J, Weizman Z, Granot E, Ron N, Okon E
Isr J Med Sci. 1983 Sep;19(9):818-23.
Ten pediatric patients investigated for chronic diarrhea, chronic weight loss, or failure to thrive were found on intestinal biopsy and/or in a duodenal aspirate to have Giardia lamblia. Serum immunoglobulin levels were normal or elevated in all patients. Three children had increased excretion of fecal fat and three other children had low D-xylose absorption. Jejunal biopsy specimens showed two severe, three moderate, and two mild morphological abnormalities, and three were normal. Except for lactase deficiency, disaccharidase activities correlated poorly with the severity of mucosal damage on biopsy. Steatorrhea was seen only with the more normal biopsies. Immunofluorescent staining of the biopsies for IgG, IgM, IgA, and secretory piece revealed no immune defects. Thus, there was no single malabsorption defect associated with giardiasis, and the specific defects did not necessarily correlate with morphological changes.
对10名因慢性腹泻、慢性体重减轻或发育不良而接受调查的儿科患者进行肠道活检和/或十二指肠抽吸检查，发现他们感染了蓝氏贾第鞭毛虫。所有患者的血清免疫球蛋白水平正常或升高。3名儿童粪便脂肪排泄增加，另外3名儿童D-木糖吸收降低。空肠活检标本显示2例严重、3例中度和2例轻度形态学异常，3例正常。除乳糖酶缺乏外，双糖酶活性与活检时黏膜损伤的严重程度相关性较差。仅在活检结果相对正常的情况下出现脂肪泻。对活检标本进行IgG、IgM、IgA和分泌片的免疫荧光染色未发现免疫缺陷。因此，贾第虫病不存在单一的吸收不良缺陷，且特定缺陷不一定与形态学改变相关。
