Rudas B, Marktl W, Swoboda W
Wien Klin Wochenschr. 1977 May 27;89(11):376-8.
Serum lipid values were determined in the first degree relatives of 31 children within the framework of a screening programme for cardiovascular-disease risk factors in schoolchildren of either sex (11 to 12 years old). Familial hyperlipoproteinaemia was not present in 5 families. The investigations revealed 12 families with hypercholesterolaemia and 2 with hypertriglyceridaemia. 12 families showed that form of hyperlipoproteinaemia which has been described in the literature as "familial combined" or "multiple type" hyperlipoproteinaemia. Spontaneous variation in serum lipids was observed in 4 out of the 12 above-mentioned children when determinations were repeated. The variability in expression of hyperlipoproteinaemia in the individual case, as well as in families, is one of the reasons for the controversy over the classification of hyperlipoproteinaemias. It is well known that hyperlipoproteinaemia, especially of the familial type, represents a significant risk factor for cardiovascular disease. Thus, it is essential to treat persons with elevated serum cholesterol or triglyceride values and to examine their relatives for hyperlipoproteinaemia.
在一项针对11至12岁的男女学童心血管疾病风险因素筛查项目中，对31名儿童的一级亲属进行了血脂值测定。5个家庭未出现家族性高脂蛋白血症。调查发现12个家庭有高胆固醇血症，2个家庭有高甘油三酯血症。12个家庭呈现出文献中描述为“家族性混合型”或“多发型”高脂蛋白血症的类型。在上述12名儿童中，有4名儿童重复测定时观察到血脂的自发变化。高脂蛋白血症在个体病例以及家庭中的表现存在变异性，这是高脂蛋白血症分类存在争议的原因之一。众所周知，高脂蛋白血症，尤其是家族性高脂蛋白血症，是心血管疾病的重要风险因素。因此，治疗血清胆固醇或甘油三酯值升高的人并检查其亲属是否患有高脂蛋白血症至关重要。
