Topley N, Williams J D
Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, UK.
Blood Purif. 1996;14(2):188-97. doi: 10.1159/000170262.
Over the past few years it has become increasingly clear that the peritoneal membrane contributes significantly to inflammatory processes occurring in the peritoneal cavity. The increasing use of continuous ambulatory peritoneal dialysis has focused attention of both the role of the mesothelium in peritoneal host defence as well as assessing the importance of the infusion of dialysis fluids on modulation of peritoneal cell function. The current review will examine our increasing knowledge of the peritoneal host defense mechanisms, particularly the involvement of the peritoneal membrane, and the mesothelium in particular, and its interaction with peritoneal macrophages. We will discuss our present knowledge of how cell viability and the secretion of inflammatory and regulatory mediators (cytokines) by the mesothelial cells are modulated following exposure to peritoneal dialysis fluid in vitro and in vivo.
在过去几年中，越来越清楚的是，腹膜对腹腔内发生的炎症过程有显著贡献。持续非卧床腹膜透析的日益广泛应用，使人们既关注间皮细胞在腹膜宿主防御中的作用，也关注评估透析液输注对腹膜细胞功能调节的重要性。本综述将审视我们对腹膜宿主防御机制，特别是腹膜，尤其是间皮细胞的参与及其与腹膜巨噬细胞相互作用的日益深入的认识。我们将讨论目前关于体外和体内暴露于腹膜透析液后间皮细胞的细胞活力以及炎症和调节介质（细胞因子）分泌如何被调节的知识。
