灭活脊髓灰质炎病毒的大鼠免疫原性试验
Rat immunogenicity assay of inactivated poliovirus.
作者信息
Bevilacqua J M, Young L, Chiu S W, Sparkes J D, Kreeftenberg J G
机构信息
Connaught Laboratories Limited, Willowdale, Ontario, Canada.
出版信息
Dev Biol Stand. 1996;86:121-7.
PMID:8785941
Abstract
A rat immunogenicity assay for IPV potency was validated and applied to routine vaccine testing as a potential alternative to the CFR Monkey Potency Assay. Potencies of pure trivalent polio, various combinations and experimental vaccines were tested with a view of producing a single dilution assay.
摘要
一种用于脊髓灰质炎灭活疫苗效力的大鼠免疫原性测定方法得到验证，并作为对猴体效力测定法的一种潜在替代方法应用于常规疫苗检测。对纯三价脊髓灰质炎疫苗、各种组合疫苗及实验性疫苗的效力进行了测试，目的是建立一种单一稀释度测定法。
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