基底核中与年龄相关的对兴奋性氨基酸易感性的降低。

Age-related decrease in vulnerability to excitatory amino acids in the nucleus basalis.

作者信息

Wenk G L, Stoehr J D, Mobley S L, Gurney J, Morris R J

机构信息

Division of Neural Systems, Memory & Aging, University of Arizona, Tucson 85724, USA.

出版信息

Neurobiol Aging. 1996 Jan-Feb;17(1):1-7. doi: 10.1016/0197-4580(95)02025-x.

DOI:10.1016/0197-4580(95)02025-x

PMID:8786791

Abstract

The present study investigated the effects of nucleus basalis magnocellularis (NBM) lesions in young (3 months), adult (9 months), and aged (24 months) rats by injections of either NMDA or AMPA upon performance of a delayed alternation task on a T maze. During phase 1 of testing, the interchoice interval (ICI) was 5 s and each rat was given 10 trials per day during phase 2, the ICI was 30 s across 10 trials per day; during phase 3, the ICI was 5 s across 20 trials per day. Analyses of variance revealed (a) a significant effect of age during phase 1 (i.e., 24-month-old rats performed worse than 3-month-old rats); (b) a significant effect of age and lesion in phase 2 (i.e., the lesions impaired choice accuracy equally in all age groups when the ICIs were 30 s); (c) a significant effect of age and lesions, and a significant interaction in phase 3 (i.e., young rats were more impaired by the lesions than were aged rats.

摘要

本研究通过向3个月大的幼鼠、9个月大的成年鼠和24个月大的老年鼠注射N-甲基-D-天冬氨酸（NMDA）或α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA），研究了基底大细胞核（NBM）损伤对其在T迷宫上进行延迟交替任务表现的影响。在测试的第1阶段，选择间隔时间（ICI）为5秒，每只大鼠每天进行10次试验；在第2阶段，ICI为30秒，每天进行10次试验；在第3阶段，ICI为5秒，每天进行20次试验。方差分析显示：（a）在第1阶段年龄有显著影响（即24个月大的大鼠表现比3个月大的大鼠差）；（b）在第2阶段年龄和损伤有显著影响（即当ICI为30秒时，损伤对所有年龄组的选择准确性损害程度相同）；（c）在第3阶段年龄和损伤有显著影响，且存在显著交互作用（即幼鼠比老年鼠受损伤的影响更大）。