[POEMS综合征：白细胞介素-6的作用与价值]

[POEMS syndrome: role and value of interleukin-6].

作者信息

Andrès E, Courouau F, Kaltenbach G, Maloisel F, Imler M

机构信息

Service de médecine interne, CHU de Strasbourg, hôpital de Hautepierre, France.

出版信息

Rev Med Interne. 1996;17(2):145-9. doi: 10.1016/0248-8663(96)82964-X.

DOI:10.1016/0248-8663(96)82964-X

PMID:8787086

Abstract

POEMS syndrome is a systemic disorder with peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. The association of POEMS syndrome with lympho-proliferative disorder is very commun. The pathogenesis remains poorly understood but implication of cytokines (interleukins 1 and 6) is suspected. We report a case of a classic POEMS syndrome (with polyneuropathy, hepatomegaly, diabetes melitus, hyperpigmentation, monoclonal IgG lambda, anasarca and solitary plasmocytoma), associated with high serum levels of interleukin 6.

摘要

POEMS综合征是一种系统性疾病，伴有周围神经病变、脏器肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变。POEMS综合征与淋巴增殖性疾病的关联非常常见。其发病机制仍知之甚少，但怀疑细胞因子（白细胞介素1和6）起了作用。我们报告一例典型的POEMS综合征（伴有多发性神经病、肝肿大、糖尿病、色素沉着、单克隆IgG λ、全身性水肿和孤立性浆细胞瘤），伴有血清白细胞介素6水平升高。