Dolphin A C
Dept of Pharmacology, Royal Free Hospital School of Medicine, London, UK.
Trends Neurosci. 1996 Jan;19(1):35-43. doi: 10.1016/0166-2236(96)81865-0.
Voltage-dependent Ca2+ channels are one of the main routes for the entry of Ca2+ into excitable cells. These channels are unique in cell-signalling terms in that they can transduce an electrical signal (membrane depolarization) via Ca2+ entry into a chemical signal, by virtue of the diverse range of intracellular Ca(2+)-dependent enzymes and processes. In a variety of cell types, currents through voltage-dependent Ca2+ channels can be increased in amplitude by a number of means. Although the term facilitation was originally defined as an increase of Ca2+ current resulting from one or a train of prepulses to depolarizing voltages, there is a great deal of overlap between facilitation by this means and enhancement by other routes, such as phosphorylation.
电压依赖性钙通道是钙离子进入可兴奋细胞的主要途径之一。这些通道在细胞信号传导方面具有独特性，即它们能够通过钙离子内流，凭借多种细胞内钙依赖性酶和过程，将电信号（膜去极化）转化为化学信号。在多种细胞类型中，通过电压依赖性钙通道的电流幅度可通过多种方式增加。尽管“易化”一词最初定义为一个或一串预脉冲使膜去极化电压导致的钙电流增加，但通过这种方式的易化与其他途径（如磷酸化）导致的增强之间存在大量重叠。
