Braszko J
Clinical Pharmacology Unit, Medical Academy of Bialystok, Poland.
Acta Neurobiol Exp (Wars). 1996;56(1):49-54. doi: 10.55782/ane-1996-1103.
In this study I attempted to assess, in rats, the role of AT1 and AT2 angiotensin receptor subtypes in the phenomenon of improved learning and memory after an intracerebroventricular (icv) injection of angiotensin II (Ang II) and Ang II (3-7). Selective AT1 (losartan, 1 mg) or AT2 (CGP 42112 A, 2 micrograms) receptor antagonist was dissolved in 2 microliters of saline and given to the left cerebral ventricle 5 min before 1 nmol Ang II or Ang II (3-7) injected in the same volume of saline to the right ventricle. Consequently, there were 9 experimental groups which underwent 3 memory oriented and 3 auxiliary tests. Ang II and Ang II (3-7) significantly improved retention of the passive avoidance and recognition memory. These effects were abolished by losartan or CGP 42112 A. Better, after Ang II and Ang II (3-7), acquisition of conditioned avoidance responses was unchanged by losartan and abolished by CGP 42112 A. None of the treatments significantly changed rats motor behaviour in open field. Losartan as well as CGP 42112 A abolished significant enhancement of apomorphine (1 mg/kg, i.p.) stereotypy caused by Ang II and Ang II (3-7). The results suggest considerable involvement of AT1 and AT2 angiotensin receptors in the cognitive enhancement produced by angiotensins.
在本研究中，我试图评估大鼠体内1型血管紧张素受体（AT1）和2型血管紧张素受体（AT2）在脑室内注射血管紧张素II（Ang II）和血管紧张素II（3 - 7）后学习记忆改善现象中的作用。将选择性AT1受体拮抗剂（氯沙坦，1毫克）或AT2受体拮抗剂（CGP 42112 A，2微克）溶于2微升生理盐水中，在向右侧脑室注射1纳摩尔Ang II或Ang II（3 - 7）（溶于相同体积生理盐水中）前5分钟注入左侧脑室。因此，共有9个实验组，进行了3项记忆相关测试和3项辅助测试。Ang II和Ang II（3 - 7）显著改善了被动回避和识别记忆的保持。这些作用被氯沙坦或CGP 42112 A消除。更好的是，在注射Ang II和Ang II（3 - 7）后，氯沙坦对条件性回避反应的习得无影响，而CGP 42112 A则消除了该反应。所有处理均未显著改变大鼠在旷场中的运动行为。氯沙坦以及CGP 42112 A消除了由Ang II和Ang II（3 - 7）引起的阿扑吗啡（1毫克/千克，腹腔注射）刻板行为的显著增强。结果表明，AT1和AT2血管紧张素受体在血管紧张素产生的认知增强中起重要作用。
