• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Enantioselective determination of oxprenolol and its metabolites in human urine by cyclodextrin-modified capillary zone electrophoresis.

作者信息

Li F, Cooper S F, Mikkelsen S R

机构信息

INRS-Santé, Université du Québec, Pointe-Claire, Canada.

出版信息

J Chromatogr B Biomed Appl. 1995 Dec 15;674(2):277-85. doi: 10.1016/0378-4347(95)00307-x.

DOI:10.1016/0378-4347(95)00307-x
PMID:8788157
Abstract

A stereospecific capillary electrophoresis assay for oxprenolol enantiomers and their basic metabolites in human urine has been developed using hydroxypropyl-beta-CD as a chiral selector in the mobile phase. The bioassay method has been validated and the detection limit from spiked urine samples is 0.2 micrograms/ml. The calibration curves are linear from 0.4 to 16 micrograms/ml. Extraction recovery ranged from 84.7 to 96.4% for all the compounds studied. The influence of various parameters on the chiral separation of oxprenolol and its basic metabolites have been investigated. Urinary excretion profiles of oxprenolol enantiomers and those of two metabolites have also been studied, following a single oral dose of racemic oxprenolol.

摘要

相似文献

1
Enantioselective determination of oxprenolol and its metabolites in human urine by cyclodextrin-modified capillary zone electrophoresis.
J Chromatogr B Biomed Appl. 1995 Dec 15;674(2):277-85. doi: 10.1016/0378-4347(95)00307-x.
2
Determination of terbutaline enantiomers in human urine by capillary electrophoresis using hydroxypropyl-beta-cyclodextrin as a chiral selector.以羟丙基-β-环糊精作为手性选择剂，采用毛细管电泳法测定人尿中的特布他林对映体。
Arch Pharm Res. 2003 Feb;26(2):120-3. doi: 10.1007/BF02976655.
3
Effect of the degree of substitution of cyclodextrin derivatives on chiral separations by high-performance liquid chromatography and capillary electrophoresis.
J Chromatogr A. 1996 Mar 29;728(1-2):423-31. doi: 10.1016/0021-9673(95)01312-1.
4
Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis.
J Chromatogr A. 2002 Mar 8;949(1-2):91-7. doi: 10.1016/s0021-9673(01)01320-6.
5
Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study.通过手性毛细管电泳评估司来吉兰、甲基苯丙胺和苯丙胺对映体的N-氧化：一项体外代谢研究。
Electrophoresis. 2004 Aug;25(16):2866-75. doi: 10.1002/elps.200406023.
6
Separation of cefoperazone enantiomers using beta-cyclodextrin as chiral additive by capillary zone electrophoresis.以β-环糊精为手性添加剂，采用毛细管区带电泳法分离头孢哌酮对映体。
Chirality. 2004 Jan;16(1):45-9. doi: 10.1002/chir.10305.
7
Separation of the enantiomers of ibuprofen and its major phase I metabolites in urine using capillary electrophoresis.利用毛细管电泳法分离尿液中布洛芬及其主要Ⅰ相代谢物的对映体。
Electrophoresis. 1998 Mar;19(3):455-60. doi: 10.1002/elps.1150190316.
8
Determination of salbutamol enantiomers by high-performance capillary electrophoresis and its application to dissolution assays.高效毛细管电泳法测定沙丁胺醇对映体及其在溶出度测定中的应用
J Pharm Biomed Anal. 1997 Oct;16(2):357-66. doi: 10.1016/s0731-7085(97)00047-2.
9
High sensitivity analysis of oxprenolol in urine by capillary electrophoresis with C18 packed on-line preconcentrator.
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jul 24;839(1-2):6-11. doi: 10.1016/j.jchromb.2005.11.046. Epub 2005 Dec 20.
10
Chiral separation of salbutamol and bupivacaine by capillary electrophoresis using dual neutral cyclodextrins as selectors and its application to pharmaceutical preparations and rat blood samples assay.以双中性环糊精为选择剂，采用毛细管电泳法对手性药物沙丁胺醇和布比卡因进行拆分，并应用于药物制剂及大鼠血样分析。
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 17;832(1):90-6. doi: 10.1016/j.jchromb.2005.12.044. Epub 2006 Jan 24.