糖尿病大鼠后肢中5-羟色胺2受体介导的反应减弱。

Attenuated 5-HT2 receptor-mediated responses in hindquarters of diabetic rats.

作者信息

James G M, Hodgson W C

机构信息

Department of Pharmacology, Monash University, Clayton, Victoria, Australia.

出版信息

Eur J Pharmacol. 1995 Dec 27;294(1):109-15. doi: 10.1016/0014-2999(95)00524-2.

DOI:10.1016/0014-2999(95)00524-2

PMID:8788422

Abstract

Vasoconstrictor responses to 5-hydroxytryptamine (5-HT), alpha-methyl-5-HT, endothelin-1, arachidonic acid and the thromboxane A2-mimetic U46619 ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)prosta-5Z,13E-dienoic acid) were obtained in blood-perfused hindquarters of 6-week streptozotocin-diabetic rats. When compared to responses obtained in hindquarters of control rats, responses to 5-HT, alpha-methyl-5-HT, and arachidonic acid were attenuated in hindquarters of diabetic rats. However, responses to endothelin-1 or U46619 were not significantly different between controls and diabetics. These results suggest that 5-HT2, but not endothelin ETA receptor-mediated responses are reduced in hindquarters of diabetic rats. The results utilising arachidonic acid and U46619 suggest that there may also be a defect in the cyclo-oxygenase cascade during diabetes.

摘要

在6周龄链脲佐菌素诱导的糖尿病大鼠的血液灌注后肢中，获得了对5-羟色胺（5-HT）、α-甲基-5-HT、内皮素-1、花生四烯酸和血栓素A2模拟物U46619（(15S)-羟基-11α,9α-(环氧亚甲基)前列腺-5Z,13E-二烯酸）的血管收缩反应。与在对照大鼠后肢中获得的反应相比，糖尿病大鼠后肢对5-HT、α-甲基-5-HT和花生四烯酸的反应减弱。然而，对照大鼠和糖尿病大鼠对内皮素-1或U46619的反应没有显著差异。这些结果表明，糖尿病大鼠后肢中5-HT2介导的反应减弱，但内皮素ETA受体介导的反应没有减弱。利用花生四烯酸和U46619的结果表明，糖尿病期间环氧化酶级联反应可能也存在缺陷。