Gauvin D V, Carl K L, Briscoe R J, Vallett M, Holloway F A
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 3190-3000, USA.
Eur J Pharmacol. 1995 Dec 27;294(1):281-8. doi: 10.1016/0014-2999(95)00550-1.
Rats were trained to discriminate between 10 mg/kg cocaine and saline injections under a fixed ratio 10 schedule of food-motivated lever press responding. Once stimulus control was achieved, reinforced test sessions were conducted to assess the degree of generalization of a wide range of cocaine doses and the cross-generalization between the cocaine training stimulus and two over-the-counter antihistaminic drugs, diphenhydramine and doxylamine, when administered with saline or in drug combinations. Cocaine produced a dose-dependent generalization to the 10 mg/kg training stimulus. Cocaine also produced mild rate-increasing effects at low test doses and response rate suppression at higher doses. Both diphenhydramine and doxylamine produced a partial generalization to the 10 mg/kg cocaine training stimulus. Drug mixtures produced complete cross-generalization with the training cue.
大鼠在以食物为动机的杠杆按压反应的固定比率10程序下接受训练，以区分10毫克/千克可卡因注射和生理盐水注射。一旦实现刺激控制，就进行强化测试环节，以评估多种可卡因剂量的泛化程度，以及可卡因训练刺激与两种非处方抗组胺药（苯海拉明和多西拉敏）之间的交叉泛化情况，这些药物与生理盐水或药物组合给药时。可卡因对10毫克/千克训练刺激产生剂量依赖性泛化。可卡因在低测试剂量时也产生轻微的速率增加效应，在高剂量时产生反应速率抑制。苯海拉明和多西拉敏都对10毫克/千克可卡因训练刺激产生部分泛化。药物混合物与训练线索产生完全交叉泛化。
