Aglan M Y, Pollard B J
University Department of Anaesthesia, Manchester Royal Infirmary, UK.
Pharmacol Ther. 1995;68(3):365-83. doi: 10.1016/0163-7258(95)02012-8.
A neuromuscular blocking agent is an essential component of many general anaesthetics. Although a great deal is known about the neuromuscular junction, the site of action of these agents, their precise mode of action remains unclear. This article reviews our present knowledge of the anatomy and physiology of neuromuscular transmission and the ways in which clinically useful drugs may modify this system. The decisions involved in clinical choice of which agent to use are described with particular respect to basic physiology and pharmacology and also to potential interactions with other drugs.
神经肌肉阻滞剂是许多全身麻醉药的重要组成部分。尽管人们对神经肌肉接头（这些药物的作用部位）已经有了很多了解，但其确切作用方式仍不清楚。本文综述了我们目前对神经肌肉传递的解剖学和生理学的认识，以及临床常用药物改变该系统的方式。文章特别从基础生理学和药理学以及与其他药物的潜在相互作用方面描述了临床选择使用哪种药物时所涉及的决策。
