Lundström V
Acta Obstet Gynecol Scand. 1977;56(3):167-72. doi: 10.3109/00016347709162115.
Serial recordings of uterine contractility during different phases of the menstrual cycle were carried out in five dysmenorrheic women, and in two subjects during the acute stage of severe dysmenorrheic pain. The sensitivity and reactivity of the uterus to intrauterine administration of small doses of PGF2alpha and PGE2 were studied. A relative insensitivity of the uterus was found in the proliferative phase and around ovulation. The uterus was highly sensitive to the stimulatory effect of PGF2alpha in the secretory phase and at menstruation but probably not more sensitive than in normal women. The corresponding results with PGE2 were rather variable in that small doses did not induce any response or slight stimulation whereas high doses occasionally caused an inhibition in the secretory phase and during menstruation. The results indicate that PGF2alpha may be a significant factor in eliciting uterine hypercontractility and dysmenorrheic pain. Whether the occasional inhibitory effect of PGE2 is of any significant importance in the pathogenesis of dysmenorrhea cannot be stated.
对五名痛经女性在月经周期不同阶段进行了子宫收缩力的连续记录，并对两名处于严重痛经急性期的受试者进行了记录。研究了子宫对宫腔内给予小剂量前列腺素F2α（PGF2α）和前列腺素E2（PGE2）的敏感性和反应性。发现子宫在增殖期和排卵期前后相对不敏感。子宫在分泌期和月经期对PGF2α的刺激作用高度敏感，但可能并不比正常女性更敏感。PGE2的相应结果变化较大，小剂量不会引起任何反应或轻微刺激，而大剂量偶尔会在分泌期和月经期引起抑制作用。结果表明，PGF2α可能是引发子宫过度收缩和痛经疼痛的一个重要因素。PGE2偶尔的抑制作用在痛经发病机制中是否具有任何重要意义尚无法确定。
