Rapola J, Pesonen E
Acta Pathol Microbiol Scand A. 1977 May;85(3):286-96. doi: 10.1111/j.1699-0463.1977.tb00429.x.
The main branch of the left coronary artery of 14 autopsied newborn babies was studied both in light and electron microscopy. Intimal and medial changes of varying severity were found in most cases. The lesions show edema and suggest insudation of the blood solutes into the vessel wall. The edematic phase is followed by proliferation of smooth-muscle and undifferentiated cells, leading to a thickening of the arterial wall. The structure of the lesions resembles the so-called preatherosclerotic changes found frequently in adults. The relationship of the neonatal coronary changes to arteriosclerosis is discussed.
对14例尸检新生儿的左冠状动脉主支进行了光镜和电镜研究。多数病例发现了不同程度的内膜和中膜改变。病变表现为水肿，提示血液溶质渗入血管壁。水肿期之后是平滑肌细胞和未分化细胞的增殖，导致动脉壁增厚。病变结构类似于成人中常见的所谓动脉粥样硬化前期改变。本文讨论了新生儿冠状动脉改变与动脉硬化的关系。
