注射可的松的非糖尿病和四氧嘧啶糖尿病去势肾上腺切除大鼠的前列腺叶和精囊。
The prostatic lobes and the seminal vesicles in non-diabetic and alloxan-diabetic castrated adrenalectomized rats injected with cortisone.
作者信息
Tisell L E, Angervall L
出版信息
Acta Pathol Microbiol Scand A. 1977 May;85(3):430-10. doi: 10.1111/j.1699-0463.1977.tb00446.x.
The growth of the prostatic lobes and the seminal vesicles was studied morphologically in alloxan-diabetic and non-diabetic castrated adrenalectomized rats. In non-diabetic but not in alloxan-diabetic rats cortisone in daily doses of 3 or 6 mg induced growth and secretory activity in the epithelium of the dorsolateral prostate, the coagulating glands and the seminal vesicles. Insulin administration to alloxan-diabetic rats could restore the effect of cortisone on these glands. This indicates that insulin deficiency per se was the main reason for the failure of cortisone to induce secretory activity of the prostatic lobes and the seminal vesicles of alloxan-diabetic rats.
对用四氧嘧啶诱导糖尿病及非糖尿病的去势肾上腺切除大鼠的前列腺叶和精囊的生长进行了形态学研究。在非糖尿病大鼠而非四氧嘧啶诱导糖尿病大鼠中，每日剂量为3或6毫克的可的松可诱导背外侧前列腺、凝腺和精囊上皮的生长及分泌活动。给四氧嘧啶诱导糖尿病大鼠注射胰岛素可恢复可的松对这些腺体的作用。这表明胰岛素缺乏本身是可的松不能诱导四氧嘧啶诱导糖尿病大鼠前列腺叶和精囊分泌活动的主要原因。
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