年龄对大鼠尾动脉中腺嘌呤核苷和核苷酸释放的影响。
The effects of age on the release of adenine nucleosides and nucleotides from rat caudal artery.
作者信息
Hashimoto M, Shinozuka K, Bjur R A, Westfall D P, Hattori K, Masumura S
机构信息
Department of Physiology, Shimane Medical University, Japan.
出版信息
J Physiol. 1995 Dec 15;489 ( Pt 3)(Pt 3):841-8. doi: 10.1113/jphysiol.1995.sp021096.
Abstract
- The spontaneous and alpha-adrenoceptor-induced release of ATP, ADP, AMP and adenosine were determined from arterial segments and from isolated endothelial cells from caudal arteries of young (5-week-old), adult (30-week-old) and old (100- to 110-week-old) Wistar rats. 2. The spontaneous (non-evoked) release of the sum total of the four purines was significantly greater from artery segments of young rats than from adult and old rats. 3. The release of the adenine nucleotides and adenosine induced by methoxamine (10 microM), an alpha 1-adrenoceptor agonist, was greater from artery segments from young rats than from old rats. 4. The spontaneous release of the sum total of the four purines was significantly greater from endothelial cells prepared from caudal arteries of young rats than of old rats. 5. The noradrenaline (10 microM)-induced release of the sum total of the four purines was significantly greater from endothelial cells prepared from caudal arteries of young rats than of old rats. 6. The levels of adenine nucleotides and adenosine, determined in plasma from anaesthetized rats, were significantly higher in young rats compared with adult and old rats. 7. These findings suggest that the release of ATP from the vascular endothelial cells is reduced with advancing age.
摘要
- 测定了来自幼年（5周龄）、成年（30周龄）和老年（100至110周龄）Wistar大鼠尾动脉的动脉段和分离的内皮细胞中ATP、ADP、AMP和腺苷的自发释放以及α-肾上腺素能受体诱导的释放。2. 幼年大鼠动脉段中四种嘌呤总和的自发（非诱发）释放显著高于成年和老年大鼠。3. α1-肾上腺素能受体激动剂甲氧明（10μM）诱导的幼年大鼠动脉段中腺嘌呤核苷酸和腺苷的释放高于老年大鼠。4. 幼年大鼠尾动脉制备的内皮细胞中四种嘌呤总和的自发释放显著高于老年大鼠。5. 去甲肾上腺素（10μM）诱导的幼年大鼠尾动脉制备的内皮细胞中四种嘌呤总和的释放显著高于老年大鼠。6. 在麻醉大鼠血浆中测定的腺嘌呤核苷酸和腺苷水平，幼年大鼠显著高于成年和老年大鼠。7. 这些发现表明，随着年龄增长，血管内皮细胞中ATP的释放减少。
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1
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Anal Biochem. 1993 May 1;210(2):262-7. doi: 10.1006/abio.1993.1194.
2
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Cardiovasc Res. 1993 Nov;27(11):1978-82. doi: 10.1093/cvr/27.11.1978.
3
Purinergic axis in cardiac blood vessels. Agonist-mediated release of ATP from cardiac endothelial cells.心脏血管中的嘌呤能轴。激动剂介导的三磷酸腺苷从心脏内皮细胞的释放。
Circ Res. 1994 Mar;74(3):401-7. doi: 10.1161/01.res.74.3.401.
4
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