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低压缺氧对大鼠抗氧化酶的影响。

Effects of hypobaric hypoxia on antioxidant enzymes in rats.

作者信息

Nakanishi K, Tajima F, Nakamura A, Yagura S, Ookawara T, Yamashita H, Suzuki K, Taniguchi N, Ohno H

机构信息

Aeromedical Laboratory, Japan Air Self-Defense Force, Tachikawa.

出版信息

J Physiol. 1995 Dec 15;489 ( Pt 3)(Pt 3):869-76. doi: 10.1113/jphysiol.1995.sp021099.

Abstract
  1. The present study was undertaken to investigate the effects of hypobaric hypoxia, equivalent to an altitude of 5500 m, on antioxidant enzymes in rats. 2. Malondialdehyde levels in serum, heart, lung, liver and kidney of hypobaric-hypoxic rats were all significantly higher than in control rats by day 21 of exposure (P < 0.05), indicating increased oxidative stress. 3. Superoxide dismutase (SOD) catalyses the conversion of the superoxide anion to H2O2 and O2. The concentration of immunoreactive Mn-SOD in the serum of hypobaric-hypoxic rats was raised significantly from day 5 onwards, whereas in liver and lung, it had decreased significantly by day 21 (P < 0.05). 4. Glutathione peroxidase (GSH-Px) catalyses H2O2 and certain lipid peroxides. By day 21, GSH-Px activity had increased significantly in the heart and lungs, but decreased significantly in the liver (P < 0.05). 5. Catalase catalyses H2O2. Catalase activity in the liver and kidney of hypobaric-hypoxic rats was significantly decreased on day 1 (P < 0.05) though levels then recovered. 6. Mn-SOD mRNA in the liver of hypobaric-hypoxic rats was induced during the experiment, the effect being exceptionally marked, especially during the first 3 days of exposure to hypobaric hypoxia. 7. These results suggest that the liver may be more vulnerable than the other organs tested to oxidative stress under hypobaric hypoxia.
摘要
  1. 本研究旨在探讨相当于海拔5500米的低压低氧环境对大鼠抗氧化酶的影响。2. 到暴露第21天时,低压低氧大鼠血清、心脏、肺、肝脏和肾脏中的丙二醛水平均显著高于对照大鼠(P<0.05),表明氧化应激增加。3. 超氧化物歧化酶(SOD)催化超氧阴离子转化为H2O2和O2。低压低氧大鼠血清中免疫反应性锰超氧化物歧化酶(Mn-SOD)的浓度从第5天起显著升高,而在肝脏和肺中,到第21天时显著降低(P<0.05)。4. 谷胱甘肽过氧化物酶(GSH-Px)催化H2O2和某些脂质过氧化物。到第21天时,心脏和肺中的GSH-Px活性显著增加,但肝脏中的活性显著降低(P<0.05)。5. 过氧化氢酶催化H2O2。低压低氧大鼠肝脏和肾脏中的过氧化氢酶活性在第1天时显著降低(P<0.05),不过随后水平恢复。6. 在实验过程中,低压低氧大鼠肝脏中的Mn-SOD mRNA被诱导,这种作用尤为显著,尤其是在暴露于低压低氧的前3天。7. 这些结果表明,在低压低氧环境下,肝脏可能比其他受试器官更容易受到氧化应激的影响。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b2d/1156855/7d80708fdf80/jphysiol00306-0251-a.jpg

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