Newman-Tancredi A, Audinot V, Jacques V, Peglion J L, Millan M J
Department of Psychopharmacology, Institut de Recherches Servier, Paris, France.
Neuropharmacology. 1995 Dec;34(12):1693-6. doi: 10.1016/0028-3908(95)00160-3.
The selective dopamine D3 receptor antagonist 3HS 14297 ((+)-[7-(N,N-dipropylamino)-5,6,7,8-tetrahydro-naphtho(2,3b)dihydro,2,3- furane]), labelled to high specific activity (145 Ci/mmol), bound to cloned human dopamine D3 receptors but displayed negligible binding to cloned human D2 receptors. 3HS 14297 exhibited rapid association and dissociation, high affinity saturable binding (Kd = 7.0 nM) and a competition binding profile highly correlated with that of [125I]iodosulpride (r = 0.98).
