Nakao K, Campos-Ortega J A
Institut für Entwicklungsbiologie Universität zu Köln, Germany.
Neuron. 1996 Feb;16(2):275-86. doi: 10.1016/s0896-6273(00)80046-x.
The segregation of neural and epidermal progenitors in Drosophila requires the activity of transcription factors encoded by the proneural genes and the genes of the E(SPL)-C. Persistent expression of two genes of the E(SPL)-C suppresses neural development. Embryos exhibit conspicuous central neural hypoplasia and lack sensory organs; imaginal sensory organs are also affected. Suppression of neural development is associated with suppression of the activity of proneural genes. DNA binding is not essential for this effect. Large cells with characteristics of neuroblasts segregate normally in embryos, but these cells fail to express various markers, and the segregated cells and/or their progeny eventually die. These findings indicate that proneural and E(spl) proteins exert antagonistic functions.
果蝇中神经祖细胞和表皮祖细胞的分离需要原神经基因和E(SPL)-C基因所编码的转录因子的活性。E(SPL)-C的两个基因持续表达会抑制神经发育。胚胎表现出明显的中枢神经发育不全且缺乏感觉器官；成虫盘感觉器官也受到影响。神经发育的抑制与原神经基因活性的抑制相关。DNA结合对于这种效应并非必需。具有神经母细胞特征的大细胞在胚胎中正常分离，但这些细胞无法表达各种标志物，并且分离出的细胞和/或其后代最终死亡。这些发现表明原神经蛋白和E(spl)蛋白发挥拮抗功能。
