构建比对序列块。

Constructing aligned sequence blocks.

作者信息

Miller W, Boguski M, Raghavachari B, Zhang Z, Hardison R C

机构信息

Department of Computer Science and Engineering, Pennsylvania State University, University Park 16802, USA.

出版信息

J Comput Biol. 1994 Spring;1(1):51-64. doi: 10.1089/cmb.1994.1.51.

DOI:10.1089/cmb.1994.1.51

PMID:8790453

Abstract

This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5' flank of the beta-globin gene.

摘要

本文提出了一种从一组两两比对中构建比对块（即无间隙多序列比对）的有效方法。该方法在检测保守序列区域方面比一些早期的块构建方法更灵敏。该技术被应用于分析蛋白质异戊二烯基转移酶中的保守区域以及检测β-珠蛋白基因5'侧翼的调控元件。