Reynoso G, Keane M, Konopka S
Am J Clin Pathol. 1977 Jul;68(1 Suppl):170-4.
Forty-three laboratories participated in an interlaboratory testing program offered by the College of American Pathologists for the radioimmunoassay (RIA) of carcinoembryonic antigen (CEA). Thirty correctly reported a sample with 1.9 ng of endogenous CEA per ml as less than 2.5 ng. For samples with added exogenous CEA at the 5.4 ng/ml level, 24 laboratories reported too low and six too high (more than 2 SD beyond the targe value). At the 8.9 ng/ml concentration, three laboratories underestimated the CEA, while 18 overestimated the sample's concentration. A similar proportion of the laboratories performed in the same manner when estimating CEA at a target concentration of 15.9 ng/ml (five underestimating and 27 overestimating the concentration). Although individual variations were large, the majority of participating laboratories can reliably distinguish normal concentrations of CEA from moderate, intermediate and large elevations.
43个实验室参与了美国病理学家学会提供的一项实验室间检测项目，该项目针对癌胚抗原（CEA）的放射免疫测定（RIA）。30个实验室正确报告了每毫升含1.9纳克内源性CEA的样本，其含量低于2.5纳克。对于添加了5.4纳克/毫升外源性CEA的样本，24个实验室报告的值过低，6个报告的值过高（超出目标值2个标准差以上）。在8.9纳克/毫升的浓度下，3个实验室低估了CEA，而18个实验室高估了样本浓度。当估计目标浓度为15.9纳克/毫升的CEA时，类似比例的实验室以相同方式进行操作（5个低估浓度，27个高估浓度）。尽管个体差异很大，但大多数参与的实验室能够可靠地将正常浓度的CEA与中度、中度和大幅升高区分开来。
