Zarrindast M R, Nami A B, Farzin D
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.
Eur Neuropsychopharmacol. 1996 May;6(2):127-33. doi: 10.1016/0924-977x(96)00002-8.
The effect of nicotine on morphine induced antinociception was studied using the tail-flick test. A low dose of nicotine (0.0001 mg/kg) which did not induce any antinociception, potentiated the morphine antinociceptive response dose-dependently. The opioid antagonist naloxone decreased the response of morphine and morphine plus nicotine. The muscarinic receptor antagonist atropine decreased the nicotine-induced potentiation of the morphine response. Sulpiride, pimozide, SCH 23390, phenoxybenzamine, propranolol, methysergide, metergoline, hexamethonium and mecamylamine did not alter the antinociception induced by nicotine and morphine. It is concluded that the potentiation of morphine-induced antinociception by nicotine may be mediated through a cholinergic mechanism.
采用甩尾试验研究了尼古丁对吗啡诱导的镇痛作用的影响。低剂量的尼古丁（0.0001毫克/千克）本身不诱导任何镇痛作用，但能剂量依赖性地增强吗啡的镇痛反应。阿片类拮抗剂纳洛酮降低了吗啡以及吗啡加尼古丁的反应。毒蕈碱受体拮抗剂阿托品降低了尼古丁诱导的吗啡反应增强作用。舒必利、匹莫齐特、SCH 23390、酚苄明、普萘洛尔、甲基麦角新碱、美替戈林、六甲铵和美卡拉明均未改变尼古丁和吗啡诱导的镇痛作用。结论是，尼古丁对吗啡诱导的镇痛作用的增强可能是通过胆碱能机制介导的。
