Farrell G C, Bhathal P S, Powell L W
Am J Dig Dis. 1977 Aug;22(8):724-8. doi: 10.1007/BF01078355.
A case of chronic hypervitaminosis A is reported in a 57-year-old woman who took vitamin preparations for alopecia. Liver biopsy of the patient showed both an increase in the number and size of fat-storing cells on light microscopy and rapidly fading green autofluorescence of vitamin A. Electron microscopy confirmed the presence of engorged fat-storing cells in the space of Disse and minor toxic changes in hepatocytes. This case illustrates the early hepatic changes of chronic hypervitaminosis A and indicates a need for restriction of sales of vitamin preparations.
报告了一例57岁女性慢性维生素A过多症病例，该女性因脱发服用维生素制剂。患者的肝脏活检显示，在光学显微镜下，储存脂肪的细胞数量和大小均增加，且维生素A的绿色自发荧光迅速消退。电子显微镜证实狄氏间隙中存在肿胀的储存脂肪细胞，肝细胞有轻微毒性变化。该病例说明了慢性维生素A过多症的早期肝脏变化，并表明需要限制维生素制剂的销售。
