异质群体中的血缘关系分析。
Consanguinity analysis in heterogeneous populations.
作者信息
Costeff H
出版信息
Am J Hum Genet. 1977 Jul;29(4):329-38.
Abstract
Consanguinity analysis can be performed in populations comprising collections of genetic isolates, and the resulting estimates can be valid and useful in phenotypes caused by numerous recessive genes, such as mental retardation and congenital nerve deafness. Maximum likelihood methods are presented for estimating gene frequency and proportions of homozygous cases of morbid phenotypes in such populations.
摘要
血缘关系分析可在由遗传隔离群集合组成的人群中进行，所得估计值对于由众多隐性基因引起的表型（如智力迟钝和先天性神经性耳聋）可能是有效且有用的。本文提出了最大似然法，用于估计此类人群中致病表型纯合病例的基因频率和比例。
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引用本文的文献
1
Consanguinity analysis of congenital deafness in Northern Israel.以色列北部先天性耳聋的血缘关系分析。
Am J Hum Genet. 1980 Jan;32(1):64-8.
2
Consanguinity analysis in Israeli mental retardates.以色列智力迟钝者的血缘关系分析。
Am J Hum Genet. 1977 Jul;29(4):339-49.
本文引用的文献
1
RECESSIVE GENES IN SEVERE MENTAL DEFECT.严重智力缺陷中的隐性基因
Am J Hum Genet. 1965 May;17(3):237-56.
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ESTIMATION OF PREVALENCE UNDER INCOMPLETE SELECTION.不完全选择情况下患病率的估计
Am J Hum Genet. 1965 May;17(3):221-36.
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A note on deaf mutism.关于聋哑症的笔记。
Ann Hum Genet. 1959 Dec;23:357-66. doi: 10.1111/j.1469-1809.1959.tb01479.x.
4
Genetic tests under incomplete ascertainment.不完全确诊情况下的基因检测。
Am J Hum Genet. 1959 Mar;11(1):1-16.
5
Parental consanguinity among Israeli mental retardates.
Acta Paediatr Scand. 1972 Jul;61(4):452-8. doi: 10.1111/j.1651-2227.1972.tb15863.x.
6
Consanguinity analysis in Israeli mental retardates.以色列智力迟钝者的血缘关系分析。
Am J Hum Genet. 1977 Jul;29(4):339-49.
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