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Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism.

作者信息

Goldstein J A, Blaisdell J

机构信息

Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

出版信息

Methods Enzymol. 1996;272:210-8. doi: 10.1016/s0076-6879(96)72025-6.

DOI:10.1016/s0076-6879(96)72025-6
PMID:8791779
Abstract
摘要

相似文献

1
Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism.
Methods Enzymol. 1996;272:210-8. doi: 10.1016/s0076-6879(96)72025-6.
2
CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population.中国傣族人群中CYP2C19基因型与S-美芬妥因4'-羟化代谢表型
Eur J Clin Pharmacol. 2002 Apr;58(1):15-8. doi: 10.1007/s00228-002-0425-x. Epub 2002 Feb 22.
3
Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.与他们的CYP2C19基因类型相关，坦桑尼亚班图人代谢奥美拉唑和甲妥英的能力降低。
Clin Pharmacol Ther. 1998 Oct;64(4):391-401. doi: 10.1016/S0009-9236(98)90070-4.
4
S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians.埃塞俄比亚人中S-美芬妥因羟基化表型与CYP2C19基因型
Pharmacogenetics. 1996 Dec;6(6):521-6. doi: 10.1097/00008571-199612000-00005.
5
Phenotyping of CYP2C19 with enantiospecific HPLC-quantification of R- and S-mephenytoin and comparison with the intron4/exon5 G-->A-splice site mutation.采用对映体特异性高效液相色谱法对R-和S-美芬妥因进行定量分析来对CYP2C19进行表型分析，并与内含子4/外显子5的G→A剪接位点突变进行比较。
Pharmacogenetics. 1995 Apr;5(2):80-8. doi: 10.1097/00008571-199504000-00004.
6
Frequencies of defective CYP2C19 alleles in a Hong Kong Chinese population: detection of the rare allele CYP2C19*4.
Clin Chem. 1999 Dec;45(12):2273-4.
7
An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians.另一个缺陷等位基因CYP2C19*5导致了高加索人中S-美芬妥英代谢不良者的表型。
Pharmacogenetics. 1998 Apr;8(2):129-35. doi: 10.1097/00008571-199804000-00006.
8
A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin.
J Pharmacol Exp Ther. 1999 Aug;290(2):635-40.
9
In vivo and in vitro measurement of CYP2C19 activity.CYP2C19活性的体内和体外测量。
Methods Enzymol. 1996;272:105-14. doi: 10.1016/s0076-6879(96)72013-x.
10
A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.人类CYP2C19中的一种新的基因缺陷：起始密码子突变导致S-美芬妥英代谢不良。
J Pharmacol Exp Ther. 1998 Jan;284(1):356-61.

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