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Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

作者信息

Smith Q R

机构信息

Neurochemistry and Brain Transport Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Pharm Biotechnol. 1996;8:285-307. doi: 10.1007/978-1-4899-1863-5_15.

DOI:10.1007/978-1-4899-1863-5_15

PMID:8791815

Abstract

摘要

相似文献

Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

Pharm Biotechnol. 1996;8:285-307. doi: 10.1007/978-1-4899-1863-5_15.

Delivery of therapeutics to the central nervous system.

Adv Drug Deliv Rev. 2012 May 15;64(7):589. doi: 10.1016/j.addr.2012.02.009. Epub 2012 Feb 24.

Drug transport into the central nervous system.

Adv Neurol. 1980;27:199-206.

Targeted lipidomics: signaling lipids and drugs of abuse.

Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):223-34. doi: 10.1016/j.prostaglandins.2005.06.005.

Passage of drugs into and out of the central nervous system.

Antimicrob Agents Chemother (Bethesda). 1965;5:1044-50.

Drug transport in the mammalian central nervous system: multiple complex systems. A critical analysis and commentary.

Pharmacology. 2000 Feb;60(2):58-73. doi: 10.1159/000028349.

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system.

Drug Metab Dispos. 2009 Jun;37(6):1226-33. doi: 10.1124/dmd.108.026377. Epub 2009 Mar 19.

Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept.

Chem Biodivers. 2009 Nov;6(11):2030-49. doi: 10.1002/cbdv.200900103.

The concept of fraction of drug transported (ft ) with special emphasis on BBB efflux of CNS and antiretroviral drugs.

Clin Pharmacol Ther. 2015 Apr;97(4):320-3. doi: 10.1002/cpt.72. Epub 2015 Feb 13.

Drug entry into and distribution within brain and cerebrospinal fluid: [14C]urea pharmacokinetics.

Am J Physiol. 1982 Mar;242(3):R339-48. doi: 10.1152/ajpregu.1982.242.3.R339.

引用本文的文献

Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique.

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Atomistic Model of Solute Transport across the Blood-Brain Barrier.

ACS Omega. 2021 Dec 29;7(1):1100-1112. doi: 10.1021/acsomega.1c05679. eCollection 2022 Jan 11.

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer.

BMC Cancer. 2015 Oct 13;15:685. doi: 10.1186/s12885-015-1672-4.

Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery.

PLoS One. 2013 Nov 20;8(11):e81051. doi: 10.1371/journal.pone.0081051. eCollection 2013.

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model.

Mol Cancer Ther. 2013 Nov;12(11):2389-99. doi: 10.1158/1535-7163.MCT-13-0132. Epub 2013 Sep 3.

Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier.

J Neurosci Methods. 2013 Sep 30;219(1):188-95. doi: 10.1016/j.jneumeth.2013.07.001. Epub 2013 Aug 2.

Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer's disease.

Pharm Res. 2013 Nov;30(11):2868-79. doi: 10.1007/s11095-013-1116-2. Epub 2013 Jun 22.

Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier.

AAPS J. 2013 Apr;15(2):299-307. doi: 10.1208/s12248-012-9434-6. Epub 2012 Dec 5.

Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterial.

Int J Nanomedicine. 2012;7:4023-36. doi: 10.2147/IJN.S32526. Epub 2012 Jul 27.

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2.

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Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

作者信息

Smith Q R

机构信息

Neurochemistry and Brain Transport Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Pharm Biotechnol. 1996;8:285-307. doi: 10.1007/978-1-4899-1863-5_15.

DOI:10.1007/978-1-4899-1863-5_15

PMID:8791815

Abstract

摘要

相似文献

Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

Pharm Biotechnol. 1996;8:285-307. doi: 10.1007/978-1-4899-1863-5_15.

Delivery of therapeutics to the central nervous system.

Adv Drug Deliv Rev. 2012 May 15;64(7):589. doi: 10.1016/j.addr.2012.02.009. Epub 2012 Feb 24.

Drug transport into the central nervous system.

Adv Neurol. 1980;27:199-206.

Targeted lipidomics: signaling lipids and drugs of abuse.

Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):223-34. doi: 10.1016/j.prostaglandins.2005.06.005.

Passage of drugs into and out of the central nervous system.

Antimicrob Agents Chemother (Bethesda). 1965;5:1044-50.

Drug transport in the mammalian central nervous system: multiple complex systems. A critical analysis and commentary.

Pharmacology. 2000 Feb;60(2):58-73. doi: 10.1159/000028349.

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system.

Drug Metab Dispos. 2009 Jun;37(6):1226-33. doi: 10.1124/dmd.108.026377. Epub 2009 Mar 19.

Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept.

Chem Biodivers. 2009 Nov;6(11):2030-49. doi: 10.1002/cbdv.200900103.

The concept of fraction of drug transported (ft ) with special emphasis on BBB efflux of CNS and antiretroviral drugs.

Clin Pharmacol Ther. 2015 Apr;97(4):320-3. doi: 10.1002/cpt.72. Epub 2015 Feb 13.

Drug entry into and distribution within brain and cerebrospinal fluid: [14C]urea pharmacokinetics.

Am J Physiol. 1982 Mar;242(3):R339-48. doi: 10.1152/ajpregu.1982.242.3.R339.

引用本文的文献

Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique.

Fluids Barriers CNS. 2024 Dec 17;21(1):100. doi: 10.1186/s12987-024-00584-y.

Atomistic Model of Solute Transport across the Blood-Brain Barrier.

ACS Omega. 2021 Dec 29;7(1):1100-1112. doi: 10.1021/acsomega.1c05679. eCollection 2022 Jan 11.

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer.

BMC Cancer. 2015 Oct 13;15:685. doi: 10.1186/s12885-015-1672-4.

Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery.

PLoS One. 2013 Nov 20;8(11):e81051. doi: 10.1371/journal.pone.0081051. eCollection 2013.

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model.

Mol Cancer Ther. 2013 Nov;12(11):2389-99. doi: 10.1158/1535-7163.MCT-13-0132. Epub 2013 Sep 3.

Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier.

J Neurosci Methods. 2013 Sep 30;219(1):188-95. doi: 10.1016/j.jneumeth.2013.07.001. Epub 2013 Aug 2.

Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer's disease.

Pharm Res. 2013 Nov;30(11):2868-79. doi: 10.1007/s11095-013-1116-2. Epub 2013 Jun 22.

Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier.

AAPS J. 2013 Apr;15(2):299-307. doi: 10.1208/s12248-012-9434-6. Epub 2012 Dec 5.

Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterial.

Int J Nanomedicine. 2012;7:4023-36. doi: 10.2147/IJN.S32526. Epub 2012 Jul 27.

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2.

J Cereb Blood Flow Metab. 2012 Nov;32(11):1989-2001. doi: 10.1038/jcbfm.2012.109. Epub 2012 Aug 1.

Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

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Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

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