Katzav S
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Crit Rev Oncog. 1995;6(2):87-97.
The binding of growth factors to membrane receptors leads to transmission of signals through the cytoplasm and into the nucleus. One of the proteins that is involved in linking tyrosine phosphorylation and subsequent signal transduction events is proto-vav. Vav was first identified as a transforming gene by the use of the nude mice tumorigenicity assay. The vav protooncogene encodes a protein with motifs usually found in nucleotide exchange factors, as well as those found in substrates of signal transduction (Src Homology 2-SH2 and Src Homology 3-SH3). Based on the transforming potential of vav, its exclusive expression in hematopoietic cells and its encoded protein structure, it is suggested that the vav protooncogene functions as an important mediator in hematopoietic signal transduction, resulting in cell growth and/or differentiation. In this review I discuss the evidence that proto-vav acts as one of the most pivotal hook elements for signal transduction in the hemopoietic system.
生长因子与膜受体的结合会导致信号通过细胞质传递并进入细胞核。参与连接酪氨酸磷酸化及后续信号转导事件的蛋白质之一是原癌基因vav。Vav最初是通过裸鼠致瘤性试验被鉴定为一种转化基因的。vav原癌基因编码的蛋白质具有通常在核苷酸交换因子中发现的基序，以及在信号转导底物（Src同源结构域2-SH2和Src同源结构域3-SH3）中发现的基序。基于vav的转化潜能、其在造血细胞中的特异性表达及其编码的蛋白质结构，有人提出vav原癌基因在造血信号转导中起重要介导作用，从而导致细胞生长和/或分化。在这篇综述中，我将讨论原癌基因vav作为造血系统信号转导中最关键的连接元件之一的证据。
