Gerulath A H, Borth R
Am J Obstet Gynecol. 1977 Aug 1;128(7):772-6. doi: 10.1016/0002-9378(77)90719-0.
Nucleic acid synthesis was studied in 26 tumor specimens, during a one-hour in vitro incubation with the addition of progesterone and estradiol-17beta. On the response scale used, deoxyribonucleic acid and ribonucleic acid synthesis decreased linearly as the logarithmic concentration of either hormone increased. Inhibition of nucleic acid synthesis was highly significant (P less than 0.001) at 80 microgram per milliliter of progesterone and at 40 microgram per milliliter of estradiol. No evidence of synergism was found when the two hormones were combined at these concentrations. In Grade I and II tumors, the effect when both hormones were combined approximated the sum of effects of the individual hormones. In Grade III tumors, little difference was seen between treatment groups.
在添加孕酮和雌二醇-17β的情况下，对26个肿瘤标本进行了一小时的体外孵育，研究了核酸合成。在所使用的反应量表上，随着两种激素对数浓度的增加，脱氧核糖核酸和核糖核酸的合成呈线性下降。当孕酮浓度为每毫升80微克、雌二醇浓度为每毫升40微克时，核酸合成的抑制作用非常显著（P小于0.001）。当这两种激素在这些浓度下联合使用时，未发现协同作用的证据。在I级和II级肿瘤中，两种激素联合使用时的效果近似于各激素单独作用效果之和。在III级肿瘤中，各治疗组之间几乎没有差异。
