Fischer G M, Swain M L
Am J Physiol. 1977 Jun;232(6):H617-21. doi: 10.1152/ajpheart.1977.232.6.H617.
Aortic collagen and elastin were quantitated in three groups of castrated and two groups of noncastrated male rats treated by intramuscular injection for 3 wk with oil, testosterone, or estradiol. The greatest differences were found between the castrated rats receiving testosterone and those receiving estradiol, the estradiol-treated rats having significantly lower total collagen, percent collagen, total elastin, and collagen/elastin (C/E), and higher percent elastin than those rats receiving testosterone. In noncastrated rats, administration of estradiol resulted in significantly lower total collagen, percent collagen, total elastin, and C/E. Systolic blood pressure was highest in rats receiving testerone and lowest in rats receiving estradiol. It is concluded that 1) estradiol in the presence or absence of testosterone decreases total accumulation of vascular connective tissue and alters the proportions of collagen and elastin so that the vessel is more distensible, 2) testosterone has an opposite but less marked effect than estradiol on vascular connective tissue, and 3) estradiol and testosterone alter blood pressure in opposite directions in the male rat.
对三组去势雄鼠和两组未去势雄鼠进行研究，通过肌肉注射油、睾酮或雌二醇，持续3周。将睾酮处理的去势大鼠与雌二醇处理的去势大鼠相比，差异最为显著。接受雌二醇处理的大鼠，其总胶原蛋白、胶原蛋白百分比、总弹性蛋白以及胶原蛋白/弹性蛋白（C/E）显著低于接受睾酮处理的大鼠，而弹性蛋白百分比则更高。在未去势大鼠中，给予雌二醇会导致总胶原蛋白、胶原蛋白百分比、总弹性蛋白和C/E显著降低。接受睾酮的大鼠收缩压最高，接受雌二醇的大鼠收缩压最低。研究得出以下结论：1）无论有无睾酮存在，雌二醇均可降低血管结缔组织的总积累量，并改变胶原蛋白和弹性蛋白的比例，使血管更具扩张性；2）睾酮对血管结缔组织的作用与雌二醇相反，但效果不如雌二醇显著；3）在雄性大鼠中，雌二醇和睾酮对血压的影响方向相反。
