Weitzman R E, Fisher D A
Am J Physiol. 1977 Jul;233(1):E37-40. doi: 10.1152/ajpendo.1977.233.1.E37.
The integrated plasma arginine vasopressin concentration (IpAVP) was determined by pooling the results of single samples collected every 3 min for 0.5 h in dehydrated, randomly hydrated, and water-loaded sheep. A linear relationship was observed between the log of the integrated AVP concentration and plasma osmolality. This relationship was tested by the bolus injection of 20 g/100 ml NaCl to both water-loaded and randomly hydrated sheep. The rise in the log of IpAVP divided by the rise in plasma osmolality was similar in both groups (P greater than 0.5) and was superimposable upon the regression line derived from steady-state observations. The data would suggest that AVP is released as an exponential function of plasma osmolality rather than as a threshold phenomenon.
通过收集脱水、随机补水和水负荷状态下的绵羊每隔3分钟采集的单次样本，持续0.5小时，来测定血浆精氨酸加压素综合浓度（IpAVP）。观察到精氨酸加压素综合浓度的对数与血浆渗透压之间存在线性关系。通过向水负荷和随机补水的绵羊静脉推注20 g/100 ml NaCl来检验这种关系。两组中IpAVP对数的升高除以血浆渗透压的升高相似（P大于0.5），并且可叠加在由稳态观察得出的回归线上。这些数据表明，精氨酸加压素作为血浆渗透压的指数函数释放，而非阈值现象。
