Ahmed F, Khan M R, Karim R, Taj S, Hyderi T, Faruque M O, Margetts B M, Jackson A A
Institute of Nutrition and Food Science, University of Dhaka, Bangladesh.
Eur J Clin Nutr. 1996 Jun;50(6):346-51.
To examine the relationship between serum retinol and biochemical indices of iron nutritional status amongst adolescent girls in urban Bangladesh.
A cross-sectional study.
Girls' high schools in Dhaka City, Bangladesh.
Adolescent girls, n = 225, aged between 12 and 15 years, from four urban schools participated in the study. Information on socio-economic conditions were obtained using a questionnaire. The height and weight of each girl were measured and a sample of blood was taken for biochemical analyses.
Twenty-two per cent of the participants were found to be anaemic (Hb < 120 g/l), 15% had subnormal serum iron ( < 7.16 mumol/l) and about 25% were iron deficient judged by serum transferrin saturation (TS < 15%). Eleven per cent of the participants had low levels of serum retinol ( < 1.05 mumol/l). Anaemic girls (n = 51) were found to have significantly lower serum retinol as well as lower packed cell volume (PCV), mean corpuscular haemoglobin concentration (MCHC), serum iron, TS, and higher serum total iron binding capacity (TIBC) compared with those with normal haemoglobin levels. When the girls were classified by serum retinol, the third with the highest serum retinol had significantly higher levels of haemoglobin, PCV, MCHC and serum iron levels. When age, family size, family income, expenditure on food, education of the parents, supplementation with vitamin A or iron and menstruation at the time of study were accounted for by multiple regression analysis, a strong relationship was found for serum retinol concentration with PCV, MCHC, haemoglobin, serum iron and TS. For 1 mumol/l change in serum retinol concentration there was a 10.1 g/l change in haemoglobin whilst taking other factors into account.
The data indicate that there is an interaction between serum retinol and biochemical indices of iron nutriture in adolescent girls who do not display any clinical signs of overt deficiency.
研究孟加拉国城市地区青春期女孩血清视黄醇与铁营养状况生化指标之间的关系。
横断面研究。
孟加拉国达卡市的女子高中。
来自四所城市学校的225名12至15岁的青春期女孩参与了本研究。通过问卷获取社会经济状况信息。测量每个女孩的身高和体重，并采集血样进行生化分析。
发现22%的参与者贫血（血红蛋白<120 g/l），15%的人血清铁水平低于正常（<7.16 μmol/l），约25%的人根据血清转铁蛋白饱和度判断为缺铁（转铁蛋白饱和度<15%）。11%的参与者血清视黄醇水平较低（<1.05 μmol/l）。与血红蛋白水平正常的女孩相比，贫血女孩（n = 51）的血清视黄醇水平以及红细胞压积（PCV）、平均红细胞血红蛋白浓度（MCHC）、血清铁、转铁蛋白饱和度均显著降低，而血清总铁结合力（TIBC）较高。当根据血清视黄醇对女孩进行分类时，血清视黄醇水平最高的第三组血红蛋白、PCV、MCHC和血清铁水平显著更高。通过多元回归分析考虑年龄、家庭规模、家庭收入、食品支出、父母教育程度、维生素A或铁补充剂以及研究时的月经情况后，发现血清视黄醇浓度与PCV、MCHC、血红蛋白、血清铁和转铁蛋白饱和度之间存在密切关系。在考虑其他因素的情况下，血清视黄醇浓度每变化1 μmol/l，血红蛋白变化10.1 g/l。
数据表明，在未表现出明显缺乏临床体征的青春期女孩中，血清视黄醇与铁营养的生化指标之间存在相互作用。
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