Ozawa Y, Tomoyasu H, Takeshita A, Shishiba Y, Yamada S, Kovacs K, Matsushita H
Department Endocrinology and Metabolism, Toranomon Hospital, Minatoku, Japan.
Horm Res. 1996;45(6):264-8. doi: 10.1159/000184803.
We report a case of a 25-year-old man with Cushing's syndrome due to an ACTH and CRH-producing thymic carcinoid. Immunohistology and radioimmunoassay demonstrated CRH and a lesser amount of ACTH in the resected primary tumor. After a symptom-free period, the tumor recurred and the patient died. Tumor obtained at autopsy contained mainly ACTH and lesser quantities of CRH. We conclude that this thymic carcinoid initially produced mainly CRH and then transformed to secrete mainly ACTH, suggesting that endocrine tumors may change their functional phenotype.
我们报告一例25岁男性因促肾上腺皮质激素（ACTH）和促肾上腺皮质激素释放激素（CRH）分泌性胸腺类癌导致库欣综合征。免疫组织化学和放射免疫分析显示，在切除的原发肿瘤中存在CRH以及少量ACTH。在一段无症状期后，肿瘤复发，患者死亡。尸检获得的肿瘤主要含有ACTH和少量CRH。我们得出结论，该胸腺类癌最初主要分泌CRH，随后转变为主要分泌ACTH，提示内分泌肿瘤可能会改变其功能表型。
