Zech K, Steinijans V W, Huber R, Kolassa N, Radtke H W
Department of Drug Metabolism and Pharmacokinetics, Byk Gulden Pharmaceuticals, Konstanz, Germany.
Int J Clin Pharmacol Ther. 1996 May;34(1 Suppl):S3-6.
Pharmacokinetics serve as a useful tool in drug development by identifying the drug's disposition and elimination characteristics, the absorption characteristics of the biopharmaceutical formulation, and the therapeutic dose regimen in various patient populations. Where two or more drugs of a class have a similar efficacy, the choice of the drug may depend upon the reproducibility of the pharmacokinetics and the minimal risk of drug interaction. Pantoprazole, a selective proton pump inhibitor, appears to meet the above criteria. As opposed to other members of the class, pantoprazole exhibits linear, predictable pharmacokinetics and lack of drug interactions.
药代动力学在药物研发中是一种有用的工具，可用于确定药物的处置和消除特征、生物制药制剂的吸收特征以及不同患者群体中的治疗剂量方案。当一类药物中有两种或更多种药物具有相似疗效时，药物的选择可能取决于药代动力学的可重复性以及药物相互作用的最小风险。泮托拉唑作为一种选择性质子泵抑制剂，似乎符合上述标准。与该类别的其他成员不同，泮托拉唑表现出线性、可预测的药代动力学且不存在药物相互作用。
