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alpha-subunit of CaM-KII increases glycine currents in acutely isolated rat spinal neurons.

作者信息

Wang R A, Randić M

机构信息

Department of Veterinary Physiology and Pharmacology, Iowa State University, Ames 50011, USA.

出版信息

J Neurophysiol. 1996 Jun;75(6):2651-3. doi: 10.1152/jn.1996.75.6.2651.

DOI:10.1152/jn.1996.75.6.2651
PMID:8793769
Abstract
  1. Here we report that in acutely isolated rat spinal dorsal horn neurons, the glycine receptor can be regulated by exogenous calcium/ calmodulin-dependent protein kinase II (CaM-KII). Intracellularly applied, the alpha-subunit of CaM-KII enhanced glycine receptor-activated current recorded with the use of the whole cell patch-clamp technique. This result suggests that the function of glycine receptor is modulated by CaM-KII, but the cellular mechanism underlying the enhancement of glycine receptor-activated current is still unknown.
摘要

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Modulation of the glycine response by Ca2+-permeable AMPA receptors in rat spinal neurones.
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