Van Parijs L, Abbas A K
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Curr Opin Immunol. 1996 Jun;8(3):355-61. doi: 10.1016/s0952-7915(96)80125-7.
Interaction of the cell-surface molecule Fas (CD95 APO-1) with its specific ligand triggers apoptotic death of T and B lymphocytes. This pathway is important for eliminating self-reactive lymphocytes and thus preventing autoimmunity. Fas is also involved in controlling injurious lymphocyte reactions in immunologically 'privileged' tissues, and may provide a strategy for reducing graft rejection.
细胞表面分子Fas（CD95 APO-1）与其特异性配体相互作用会触发T淋巴细胞和B淋巴细胞的凋亡性死亡。该途径对于清除自身反应性淋巴细胞从而预防自身免疫至关重要。Fas还参与控制免疫“豁免”组织中有害的淋巴细胞反应，并且可能为减少移植排斥提供一种策略。
