磷脂酰肌醇3-激酶相关激酶

Phosphatidylinositol 3-kinase related kinases.

作者信息

Abraham R T

机构信息

Department of Immunology, Mayo Clinic/Foundation, Rochester, MN 55905, USA.

出版信息

Curr Opin Immunol. 1996 Jun;8(3):412-8. doi: 10.1016/s0952-7915(96)80132-4.

DOI:10.1016/s0952-7915(96)80132-4

PMID:8793996

Abstract

Studies in yeast, files and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase. These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical manifestations ranging from immunodeficiency to cancer.

摘要

对酵母、果蝇和哺乳动物细胞的研究发现了一个新的信号转导激酶家族，它们与磷脂酰肌醇3激酶具有进化关系。这些与磷脂酰肌醇3激酶相关的酶在DNA修复、V(D)J重组和细胞周期检查点中起关键作用，其功能障碍会导致从免疫缺陷到癌症等一系列临床表现。