Kägi D, Hengartner H
Ontario Cancer Institute, c/o Prof T Mak, 610 University Avenue, Toronto, Ontario M5G2M9, Canada.
Curr Opin Immunol. 1996 Aug;8(4):472-7. doi: 10.1016/s0952-7915(96)80033-1.
The assessment of the role of T-cell-mediated cytotoxicity in immunity to viral infections has been difficult to address directly and therefore has been controversial. Recent experiments with perforin-deficient mice have shown that cytotoxicity is crucial for the resolution of infection with lymphocytic choriomeningitis virus but not for the resolution of infection with vaccinia, vesicular stomatitis, Semliki Forest or influenza virus. These findings may reflect the general pattern that T-cell-mediated cytotoxicity is crucial only for the resolution of infections with noncytopathic viruses, whereas infections with cytopathic viruses are mainly controlled by soluble mediators such as antibodies and interferons.
评估T细胞介导的细胞毒性在抗病毒感染免疫中的作用一直难以直接进行，因此存在争议。最近对穿孔素缺陷小鼠的实验表明，细胞毒性对于解决淋巴细胞性脉络丛脑膜炎病毒感染至关重要，但对于解决痘苗病毒、水疱性口炎病毒、Semliki森林病毒或流感病毒感染并非至关重要。这些发现可能反映了一种普遍模式，即T细胞介导的细胞毒性仅对解决非细胞病变病毒感染至关重要，而细胞病变病毒感染主要由抗体和干扰素等可溶性介质控制。
