Diversity and function of presynaptic calcium channels in the brain.

Calcium channels in presynaptic nerve terminals are essential for neurotransmitter release, and current research has provided evidence for the involvement of a multitude of Ca2+ channel types. The diversity of Ca2+ channel structure and distribution in the brain suggests specific functional roles. Modulation by interaction with other proteins and/or by phosphorylation/dephosphorylation reactions enhances the regulatory impact of these channels on brain function.