Frerking M, Wilson M
Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, University of California, Davis, 95616, USA.
Curr Opin Neurobiol. 1996 Jun;6(3):395-403. doi: 10.1016/s0959-4388(96)80125-5.
A fundamental issue in synaptic physiology is whether the postsynaptic response to a quantum of transmitter is limited by the number of receptors available. Fierce debate over the past few years has yielded no consensus. The majority of evidence suggests that the degree of receptor occupancy is likely to be sensitive to a number of factors, including the detailed anatomy of the synaptic cleft and the time course of transmitter clearance, and is probably different from one synapse to the next.
突触生理学中的一个基本问题是，突触后对一个递质量子的反应是否受可用受体数量的限制。在过去几年里，激烈的争论尚未达成共识。大多数证据表明，受体占据程度可能对许多因素敏感，包括突触间隙的详细解剖结构和递质清除的时间进程，而且可能因突触而异。
