Burnashev N
Max-Planck-Institut für medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D-69120 Heidelberg, Germany.
Curr Opin Neurobiol. 1996 Jun;6(3):311-7. doi: 10.1016/s0959-4388(96)80113-9.
Molecular cloning of ionotropic glutamate receptors and the development of new measurement techniques have significantly advanced our understanding of the molecular mechanisms controlling ligand-mediated entry of Ca2+ into neurons of the mammalian CNS. Recent studies have demonstrated that various types of glutamate receptors expressed in different nerve cells are permeable to Ca2+ to variable extents, depending on the structural peculiarities of the subunits and their composition in a particular cell. This diversity provides a regulable pathway for Ca2+ entry during synaptic transmission. The fractional contribution of this Ca2+ to the total synaptic current might be a substantial means of elevating the intracellular Ca2+ concentration over a wide temporal range.
离子型谷氨酸受体的分子克隆以及新测量技术的发展，极大地推动了我们对控制配体介导的Ca2+进入哺乳动物中枢神经系统神经元分子机制的理解。最近的研究表明，不同神经细胞中表达的各种类型的谷氨酸受体对Ca2+具有不同程度的通透性，这取决于亚基的结构特性及其在特定细胞中的组成。这种多样性为突触传递过程中Ca2+的进入提供了一条可调节的途径。这种Ca2+对总突触电流的部分贡献可能是在很宽的时间范围内提高细胞内Ca2+浓度的一种重要方式。
