Smith D P
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75235-9111, USA.
Curr Opin Neurobiol. 1996 Aug;6(4):500-5. doi: 10.1016/s0959-4388(96)80056-0.
Genetic approaches are beginning to provide valuable insights into the function of specific gene products in olfaction. Analysis of Drosophila mutants that affect olfactory responses are defining components of the olfactory signaling mechanisms. Mutations in the genes paralytic and Scutoid cause olfactory defects, as do mutations in genes encoding products that mediate visual responses. In addition, members of the family of invertebrate odorant-binding proteins have been identified in Drosophila and may play an important role in the olfactory process.
遗传学方法开始为嗅觉中特定基因产物的功能提供有价值的见解。对影响嗅觉反应的果蝇突变体的分析正在确定嗅觉信号传导机制的组成部分。“麻痹”基因和“类盾片”基因的突变会导致嗅觉缺陷,编码介导视觉反应产物的基因发生突变时也会如此。此外,在果蝇中已鉴定出无脊椎动物气味结合蛋白家族的成员,它们可能在嗅觉过程中发挥重要作用。