el-Feky S A, Abd el-Samii Z K
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.
Pharmazie. 1996 Aug;51(8):540-3.
Convenient Syntheses of derivatives of the pyrazolo[3,4-d]pyrimidines from 1-(4-benzyl-1-phthalazinyl)-3-amino-4-cyano-5-methylpyrazole (1) and carbon disulphide, aryl isothiocyanates, nitriles or guanidine are described. Derivatives of compound 1 undergo cyclization to the titled ring system by action of dimethylformamide dimethylacetal or hydrogen sulphide followed by treatment with triethylamine. Some of the new compounds were studied as antihypertensive agents.
描述了由1-(4-苄基-1-酞嗪基)-3-氨基-4-氰基-5-甲基吡唑(1)与二硫化碳、芳基异硫氰酸酯、腈或胍方便地合成吡唑并[3,4-d]嘧啶衍生物的方法。化合物1的衍生物通过二甲基甲酰胺二甲基缩醛或硫化氢作用，然后用三乙胺处理，环化生成标题环系。对一些新化合物作为抗高血压药物进行了研究。
