Morse L S, Benner J D, Hjelmeland L M, Landers M B
Department of Ophthalmology, University of California, Davis, Sacramento, 95816, USA.
Br J Ophthalmol. 1996 Jul;80(7):658-62. doi: 10.1136/bjo.80.7.658.
AIMS/BACKGROUND: Human recombinant tissue plasminogen activator (rt-PA) fibrinolysis of subretinal haemorrhage with concomitant removal has been shown to reverse the natural history of photoreceptor degeneration in experimental subretinal haemorrhages if evacuated within 7 days. The aim of the study was to determine whether fibrinolysis of subretinal haemorrhage without concomitant removal would offer a simpler approach with similar photoreceptor sparing.
A neodymium YAG laser was used to create experimental subretinal haemorrhages beneath the holangiotic retina of the cat. Tissue plasminogen activator (10 micrograms/ml) was injected into 4 day old subretinal haemorrhages to evaluate its effect on altering the natural history of retinal degeneration. Light and electron microscopy were used to study the histopathological effect.
The injection of rt-PA into large 4 day old subretinal haemorrhages without concomitant removal did not alter the natural history of retinal degeneration. In fact, a second focus of retinal degeneration occurred at a gravity dependent inferior site where the subretinal haemorrhages had migrated.
There was no therapeutic benefit from the injection of rt-PA into subretinal haemorrhages without con-comitant removal in this cat model.
目的/背景：已表明，在7天内清除视网膜下出血并同时进行人重组组织型纤溶酶原激活剂（rt-PA）纤维蛋白溶解，可逆转实验性视网膜下出血中光感受器变性的自然病程。本研究的目的是确定不伴有清除的视网膜下出血纤维蛋白溶解是否会提供一种更简单的方法并具有相似的光感受器保留效果。
使用钕钇铝石榴石激光在猫的全血管化视网膜下方制造实验性视网膜下出血。将组织型纤溶酶原激活剂（10微克/毫升）注入4日龄的视网膜下出血中，以评估其对改变视网膜变性自然病程的影响。使用光学显微镜和电子显微镜研究组织病理学效应。
在不伴有清除的情况下，将rt-PA注入4日龄的大视网膜下出血中并未改变视网膜变性的自然病程。事实上，在视网膜下出血迁移到的重力依赖下方部位出现了第二个视网膜变性病灶。
在该猫模型中，不伴有清除而将rt-PA注入视网膜下出血没有治疗益处。
